
Caryn Oshiro, PhD, MS, RD is a collaborative investigator at CIHR who uses a life-course approach to studying obesity as a chronic progressive disease and its relationship to other chronic diseases, including cardiovascular disease, diabetes, and cancer. She also studies the impacts of new and effective pharmacological treatments for obesity and diabetes on patient health and lifestyle (nutrition and physical activity).
Much of Dr. Oshiro’s current research centers on maternal and child health, including research on the impact of gestational diabetes screening on adverse pregnancy outcomes, and the relationship between preconception, pregnancy, and infancy weight trajectories on childhood obesity. This work has included her role as KPHI Principal Investigator on the innovative GO MOMs study, which is using continuous glucose monitoring during pregnancy to investigate the relationship between metabolic outcomes in mothers and their offspring. Dr. Oshiro also studies the roles of racial and ethnic disparities and food insecurity in biopsychosocial health throughout the life course.
Dr. Oshiro joined CIHR in 2006 and has developed deep expertise in using electronic health record data to examine health disparities in obesity, diabetes, and cancer; screening for chronic diseases and other conditions within health care systems; understanding predictors of healthy aging in the older adult using risk prediction models; and conducting large, pragmatic, randomized trials of disease screening and prevention interventions in underserved populations. She has also led NIH- and PCORI-funded multi-site projects as site PI. These projects have ranged from large, longitudinal cohort studies to health behavior interventions. Locally, she has created collaborative research networks focused on cancer and nutritional studies with the University of Hawaii. She has worked with primary care providers at Kaiser Permanente Hawaii on efforts to understand prevalence of disease and health conditions and improve practice using electronic medical records data and research methodology.
Dr. Oshiro completed an MS in nutritional sciences and a PhD in epidemiology from the University of Hawaii; she is also a Registered Dietician and completed a clinical dietetic internship at the University of Michigan Hospitals in Ann Arbor. Her early experience as a clinical RD as part of interdisciplinary health care teams in the Michigan, Adventist Health, and Kaiser Permanente health care systems has given her invaluable clinical inpatient and outpatient expertise, as well as experience working with diverse populations. Now, as a researcher connected to the health care system, she uses both her epidemiologic and clinical experience to translate research into knowledge for use by health care providers and the broader community.
Selected Publications:
- Rodriguez LA, Finertie H, Neugebauer RS, Gosiker B, Thomas TW, Karter AJ, Gilliam LK, Oshiro C, An J, Simonson G, Cassidy-Bushrow AE, Dombrowski S, Nolan M, O'Connor PJ, Schmittdiel JA. Race and ethnicity and pharmacy dispensing of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes. Lancet Reg Health Am. 2024 Jun;34:100759. doi: 10.1016/j.lana.2024.100759. eCollection 2024 Jun. PubMed PMID: 38745886; PubMed Central PMCID: PMC11091531.
- Oshiro CES, Frankland TB, Rosales AG, Hillier TA, Perrin N. First year infant weight trajectories predict overweight/obesity at age 2 in a diverse population. Obes Res Clin Pract. 2022 Sep-Oct;16(5):434-436. doi: 10.1016/j.orcp.2022.08.007. Epub 2022 Aug 25. PubMed PMID: 36030170
- Oshiro CE, Hillier TA, Edmonds G, Peterson M, Hill PL, Hampson S. Vitamin D deficiency and insufficiency in Hawaii: Levels and sources of serum vitamin D in older adults. Am J Hum Biol. 2022 Mar;34(3):e23636. doi: 10.1002/ajhb.23636. Epub 2021 Jul 2. PubMed PMID: 34213035; PubMed Central PMCID: PMC8720322.
- Oshiro CES, Frankland TB, Mor J, Wong CP, Martinez YT, Aruga CKK, Honda S. Lung Cancer Screening by Race and Ethnicity in an Integrated Health System in Hawaii. JAMA Netw Open. 2022 Jan 4;5(1):e2144381. doi: 10.1001/jamanetworkopen.2021.44381. PubMed PMID: 35050353; PubMed Central PMCID: PMC8777569.
- Hillier TA, Pedula KL, Ogasawara KK, Vesco KK, Oshiro C, Van Marter JL. Impact of earlier gestational diabetes screening for pregnant people with obesity on maternal and perinatal outcomes. J Perinat Med. 2022 Oct 26;50(8):1036-1044. doi: 10.1515/jpm-2021-0581. Print 2022 Oct 26. PubMed PMID: 35534914; PubMed Central PMCID: PMC9519183.
- Hillier TA, Pedula KL, Ogasawara KK, Vesco KK, Oshiro CES, Lubarsky SL, Van Marter J. A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening. N Engl J Med. 2021 Mar 11;384(10):895-904. doi: 10.1056/NEJMoa2026028. PubMed PMID: 33704936; PubMed Central PMCID: PMC9041326.
- Hillier TA, Ogasawara KK, Pedula KL, Vesco KK, Oshiro CES, Van Marter JL. Timing of Gestational Diabetes Diagnosis by Maternal Obesity Status: Impact on Gestational Weight Gain in a Diverse Population. J Womens Health (Larchmt). 2020 Aug;29(8):1068-1076. doi: 10.1089/jwh.2019.7760. Epub 2020 Apr 24. PubMed PMID: 32330405; PubMed Central PMCID: PMC7461990.
- Oshiro CES, Frankland TB, Rosales AG, Perrin NA, Bell CL, Lo SHY, Trinacty CM. Fall Ascertainment and Development of a Risk Prediction Model Using Electronic Medical Records. J Am Geriatr Soc. 2019 Jul;67(7):1417-1422. doi: 10.1111/jgs.15872. Epub 2019 Mar 15. PubMed PMID: 30875089.
- Pedula KL, Hillier TA, Ogasawara KK, Vesco KK, Lubarsky S, Oshiro CES, VanMarter J. A randomized pragmatic clinical trial of gestational diabetes screening (ScreenR2GDM): Study design, baseline characteristics, and protocol adherence. Contemp Clin Trials. 2019 Oct;85:105829. doi: 10.1016/j.cct.2019.105829. Epub 2019 Aug 16. PubMed PMID: 31425751; PubMed Central PMCID: PMC6939663
- Hillier TA, Pedula KL, Vesco KK, Oshiro CE, Ogasawara KK. Impact of Maternal Glucose and Gestational Weight Gain on Child Obesity over the First Decade of Life in Normal Birth Weight Infants. Matern Child Health J. 2016 Aug;20(8):1559-68. doi: 10.1007/s10995-016-1955-7. PubMed PMID: 27154523; PubMed Central PMCID: PMC9870031.
- Oshiro CE, Novotny R, Grove JS, Hurwitz EL. Race/Ethnic Differences in Birth Size, Infant Growth, and Body Mass Index at Age Five Years in Children in Hawaii. Child Obes. 2015 Dec;11(6):683-90. doi: 10.1089/chi.2015.0027. Epub 2015 Nov 12. PubMed PMID: 26561722.
- Novotny R, Oshiro CE, Wilkens LR. Prevalence of Childhood Obesity among Young Multiethnic Children from a Health Maintenance Organization in Hawaii. Child Obes. 2013 Feb;9(1):35-42. doi: 10.1089/chi.2012.0103. PubMed PMID: 23373877; PubMed Central PMCID: PMC3621358.
Full List of Publications:
Studies:
- MATTRACK: THE IMPACT OF PRECONCEPTION MATERNAL WEIGHT TRAJECTORIES ON MATERNAL, PREGNANCY, AND CHILD OUTCOMES
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MatTrack is an electronic medical record - based retrospective study of pregnant individuals selected from various Kaiser Permanente health care systems. The objective of this study is to examine the impact of maternal preconception weight trajectories on pregnancy weight gain and retention, pregnancy outcomes, and child outcomes.
Sponsor: NIH/NIDDK
Subcontract to: Center for Health Research, Kaiser Permanente Northwest
KPHI Co-Investigator: Caryn Oshiro, PhD
- POSIT: PRECONCEPTION BARIATRIC SURGERY AND CHILD HEALTH OUTCOMES STUDY
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The POSIT study aims to estimate the effects of preconception weight loss by maternal metabolic-bariatric surgery on infant and child body size, growth, and related outcomes. The study cohort is sampled from Kaiser Permanente health care systems located in the Pacific Northwest, Southern California, and Hawaii.
Sponsor: NIH/NIDDK
Subcontract to: Oregon Health & Science University (OHSU)
KPHI Principal Investigator: Caryn Oshiro, PhD
- GOMOMS: CHARACTERIZING, BY TRIMESTER, CONTINUOUS GLUCOSE MONITORING MEASUREMENTS FOR DETERMINING EFFECTS ON MATERNAL & OFFSPRING METABOLIC SEQUELAE
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Gestational diabetes (GDM) is a type of diabetes that develops during pregnancy and increases the risk of pregnancy and birth complications. New tests may allow doctors to identify women with GDM earlier and more accurately than the tests currently being used, but we need to understand them better. The GO MOMs study is recruiting 400 pregnant individuals and screening them using both traditional and new GDM screening tools at 12, 20, and 28 weeks of pregnancy to determine how well these tools identify people who are at risk of pregnancy complications and need treatment.
Sponsor: NIH/NIDDK
KPHI Principal Investigator: Caryn Oshiro, PhD
- GO MOMS: NUTRITION STUDY
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The GO MOMs Nutrition Study is an observational substudy nested within the GO MOMs study (described above). The goal of the study is to describe maternal diet quality and composition in a diverse cohort of pregnant individuals and to study the relationship between maternal diet and outcomes including maternal glycemia, maternal insulin physiology, infant birth weight, and infant fat mass.
Sponsor: NIH/Office of Nutrition Research
KPHI Principal Investigator: Caryn Oshiro, PhD
- ON TARGET DM: COMPARISON OF TYPE 2 DIABETES PHARMACOTHERAPY REGIMENS USING TARGETED LEARNING
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This study is using observational data from real-world clinical settings to directly compare the impacts of different Type 2 Diabetes treatment strategies on cardiovascular outcomes and other outcomes that are important to patients.
Sponsor: PCORI
KPHI Co-Investigator: Caryn Oshiro, PhD