David Ng, MD, is a staff medical geneticist at CIHR at Kaiser Permanente Hawaii. He completed his MD from Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine; an Internal Medicine residency at David Grant U.S. Air Force Medical Center; and a fellowship in Medical Genetics at the National Institutes of Health. Dr. Ng joined CIHR in 2019 and has expertise in precision medicine, pharmacogenomics, cancer genetics, and cardiogenetics. His primary research interests focus on studying individual genetic variability and its interaction with the microbiome, environment, lifestyle to develop targeted treatment for the individual patient.
Dr. Ng’s research has contributed to the fields of dysmorphology, rare genetic diseases, cancer genetics, cardiovascular genetics, pharmacogenetics, precision medicine and secondary findings. He cloned the causative gene for Lenz microphthalmia and familial chordoma. Dr. Ng was part of the group at NHGRI who addressed the subject of secondary findings (genetic changes in a gene unrelated to the primary purpose for the genetic testing) and has published on the interpretion of secondary findings in cardiac and cancer gene variants in healthy cohorts.
Before joining CIHR, Dr. Ng was a Clinical Specialty Consultant with the National Human Genome Research Institute, National Institutes of Health where he was the principal investigator on a pharmacogenetic project studying the effects of pharmacogenetic variation on plasma statin levels. He was a co-investigator on the ClinSeq® project and attending geneticist for the medical genetics fellowship training program at the National Institutes of Health.
- Ng D, Thakker N, Corcoran CM, Donnai D, Perveen R, Schneider A, Hadley DW, Tifft C, Zhang L, Wilkie AOM, van der Smagt JJ, Gorlin RJ, Burgess SM, Bardwell VJ, Black GCM, Biesecker LG. Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. Nat Genet 2004; 36:411-416. [PMID: 15004558].
- Yang XR*, Ng D*, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM, Kelley MJ. T (Brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet 2009; 41:1176-8. (*Contributed equally to this work). [PMID: 19801981].
- Ng D, Johnston JJ, Teer JK, Singh LN, Peller LC, Wynter JS, Lewis KL, Cooper DN, Stenson PD, Mullikin JC, Biesecker LG; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program. Interpreting secondary cardiac disease variants in an exome cohort. Circ Cardiovasc Genet 2013, 6(4): 337-46. [PMID: 23861362].
- Ng D, Hong CS, Singh LN, Johnston JJ, Mullikin JC, Biesecker LG. Assessing the capability of massively parallel sequencing for opportunistic pharmacogenetic screening. Genet Med 2017, 19(3):357-361 [PMID:27537706].